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The Genome of Cavities

Evolutionary and population genomics of the cavity causing bacteria Streptococcus mutans, Mol Biol Evol (2012) doi: 10.1093/molbev/mss278 First published online: December 10, 2012
"A set of 14 genes was identified as being under positive selection, most of which were involved in either sugar metabolism or acid tolerance. Analysis of the core genome suggested that among 73 genes present in all isolates of S. mutans but absent in other species of the mutans taxonomic group, the majority can be associated with metabolic processes that could have contributed to the successful adaptation of S. mutans to its new niche, the human mouth, and with the dietary changes that accompanied the origin of agriculture."
Study showing that the metabolic changes in human physiology negatively impacted the development of bacteria, specifically Streptococcus mutans, and coincided with an exponential growth in their development approximately 10,000 years ago - during the development of Agriculture in early civilization.

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